Vice Chancellor and Vice Rector for Research and Innovation - Unimi
13:05 - 13:10
Opening of the event
Opening remarks
Giuseppe Testa
University of Milan, Human Technopole and European Institute of Oncology, Milan, Italy
Session 1: Epigenetic regulation and inheritance in development and differentiation
Chair of Session 1: Epigenetic regulation and inheritance in development and differentiation
Diego Pasini
13:15 - 13:40
Session 1: Epigenetic regulation and inheritance in development and differentiation
Mechanisms of Transgenerational Epigenetic Inheritance
Victor G. Corces
Dpt. of Human Genetics, Emory University School of Medicine, Atlanta, US
13:40 - 14:05
Session 1: Epigenetic regulation and inheritance in development and differentiation
Epigenetic Mechanisms in Early Mammalian Development
Maria Elena Torres-Padilla
Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, München, Germany
14:05 - 14:30
Session 1: Epigenetic regulation and inheritance in development and differentiation
Gene Regulation through Mitosis
Pablo Navarro Gil
Institut Pasteur, Paris, France
14:30 - 14:55
Session 1: Epigenetic regulation and inheritance in development and differentiation
Hypertranscription in Development, Stem Cells and Regeneration
Miguel Ramalho-Santos (by remote)
The Lunenfeld-Tanenbaum Research Institute, Toronto, Canada
14:55 - 15:10
Session 1: Epigenetic regulation and inheritance in development and differentiation
A Novel Program of Epigenetic Enhancer Priming in the Regulation of Key Developmental Gene Networks during Mammalian Embryogenesis
Christopher Todd (by remote)
Scientist
Altos Labs
15:30 - 15:45
Session 1: Epigenetic regulation and inheritance in development and differentiation
CRISPR/CAS9 Editing of DNMT3B Mutations in ICF1-patient iPSCs Promises and Challenges in Correcting an Inherited Epigenetic Disease
Maria R Matarazzo (by remote)
PI
Institute of Genetics and Biophysics Adriano Buzzati Traverso
15:45 - 15:47
Session 1: Epigenetic regulation and inheritance in development and differentiation
Poster teaser - The Molecular Basis of Epigenetic Inheritance in Humans
Sarah Stucchi
PhD
Human Technopole
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Chair of Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Elena Battaglioli
15:47 - 16:12
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Mechanisms of Epigenetic Regulation in Development and Disease
Alexander Meissner (by remote)
Max Planck Institute for Molecular Genetics, Berlin, Germany
16:12 - 16:27
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
LINE1 Transcripts Regulate the Chromatin Conformation of Human T-cell Quiescence and Exhaustion
Beatrice Bodega
Group Leader
Istituto Nazionale di Genetica Molecolare (INGM)
16:27 - 16:52
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Histone Signature and DNA Repair in Embryonic Stem Cells
Eva Bártová
Institut of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
16:52 - 17:07
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Balancing H31 And H33 Histone Variants During DNA Replication Reveals their Controlled Enrichment at Pericentromeric Heterochromatin Throughout Cell Cycle and Differentiation
Stefano Arfè
PhD student
Institut Curie
17:07 - 17:09
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Poster teaser - Chromatin Conformation of Muscle Stem Cells in Physiological and Pathological Muscular Aging
Philina Santarelli
PhD Candidate
INGM
17:09 - 17:11
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Poster teaser - Unveiling the Chromatin Organization Mediated by LINE1 Elements in Human T-cell Quiescence
Lorenzo Salviati
PhD student
INGM - Istituto Nazionale Genetica Molecolare
17:11 - 17:13
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Poster teaser - Cell Cycle Clock Regulates the Epigenetic Landscape of AML Cells and Determines Sensitivity to LSD1 Inhibition
Kourosh Hayatigolkhatmi
PhD Student
IEO
17:15 - 17:17
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Poster teaser - About Robotics and the Quest for a Wholistic Approach to the Definition of Cell Identity in Brain Development and Pathology
Martina Polenghi
PHD
Fondazione Human Technopole
17:17 - 17:19
Session 2: Nuclear organization and epigenetic regulation in stem cells and pluripotency
Poster teaser - The Acetyltransferase P300 Is Recruited to Enhancers by LNCSMAD7 to Control Stem-Cell Identity
Mara Maldotti
Assistant Professor
Università di Torino
5July
Coffee Break
10:30 - 10:50
Lunch
12:30 - 13:30
Coffee Break
14:54 - 15:15
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Chair of Session 3: Chromatin Architecture across Replication, Transcription and Splicing Chair person Francesco Ferrari Sala
Francesco Ferrari
Principal Investigator
IFOM
09:00 - 09:25
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Beyond Motif: Guiding Sites of Transcription Factor Binding by DNA Modifications
Dirk Schubeler
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
09:25 - 09:40
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Evolution Increases Stress-Response Complexity in Higher Primates Extending Rbfox1 Splicing Activity to LSD1 Modulation
Chiara Forastieri
POSTDOC
University of Milan
09:40 - 10:05
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Histone Variants and Chaperones in Shaping Chromatin and Cell Fate
Genevieve Almouzni (by remote)
Centre de Recherche de l'Institut Curie, Paris, France
10:05 - 10:30
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Enhancer Function in the 3D Genome: Is Close Enough Enough?
Wendy Bickmore
Medical Research Council Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK
10:50 - 10:52
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Poster teaser - Hooked Up from a Distance Functional Study of 3D Enhancer-Promoter Interaction Networks in Neural Stem Cells, and their Relevance for Neurodevelopmental Disease
Miriam Pagin (by remote)
10:52 - 10:54
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Poster teaser - A Network-Based Framework to Unravel Gene Regulation Dynamics during Craniofacial Development
Daniele Capocefalo
Postdoctoral Researcher
Human Technopole
10:54 - 10:56
Session 3: Chromatin Architecture across Replication, Transcription and Splicing
Poster teaser - Understanding Early Embryogenesis Regulation Through Proteomics Approaches
Maria Teresa Alejo Vinogradova
PhD Candidate
Radboud University
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Chair of Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Jose Davila Velderrain
10:56 - 11:21
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Single Cell Multi-omics Landscape of Development and Ageing
Wolf Reik (by remote)
Babraham Institute, Cambridge, UK
11:21 - 11:36
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Replication Stress Induces Cell Fate Reprogramming in Embryonic Stem Cells
Vincenzo Costanzo
PI
IFOM • Istituto Fondazione di Oncologia Molecolare ETS
11:36 - 11:51
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Integrative Analysis of Aberrant Epigenetic Features in Triple Negative Breast Cancer
Tiziana Bonaldi
PI
European Institute of Oncology, Milan
11:51 - 12:16
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
iPSC-derived Brain Organoids Reveal Widespread DNA de-methylation in Huntington's Disease
Eran Meshorer
Edmond and Lily Center for Brain Sciences, The Hebrew University, Jerusalem, Israel
12:16 - 12:18
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Multi-omics Profiling Uncovers Alterations in Thymic Epithelial Tumors and Mechanistic Insight into GTF2I Involvement
Sude Beskardes
Fellow
European Institute of Oncology
12:18 - 12:20
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Prospective Isolation of Cancer Stem Cells by Single Cell Trained Sorting in High Grade Serous Ovarian Cancer
Bianca Barzaghi
PhD
Istituto Europeo di Oncologia
12:20 - 12:22
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Deciphering Epigenetics Role in Huntington Disease Cell Lines
Paola Conforti
Tecnico di laboratorio
dipartimento di Bioscienze, Università degli Studi di Milano
12:22 - 12:24
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Patient-Specific Modelling of Syndromic Autism Uncovering the Role of ADNP In Chromatin Dysregulation
Ludovico Rizzuti
Postdoc
European Institute of Oncology
12:24 - 12:26
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Gabriele-De Vries Syndrome (GADEVS) Disentangling the Role of YY1 Across Human Neuronal Models at Single-Nuclei Resolution
Marlene F Pereira
PhD student
European Institute of Oncology (IEO)
12:26 - 12:28
Session 4: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - The Impact of Replication Stress on the Epigenome of Embryonic Stem Cells
Christelle El Kai
PhD
SEMM Foundation
Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Chair of Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Simona Lodato
13:30 - 13:55
Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Gene Regulation and Cognition
Raymond Poot
Erasmus MC University Medical Center, Rotterdam, The Netherlands
13:55 - 14:10
Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Single-Cell Study of Epigenetic Dynamics in Cell Diversification during Zebrafish Development
Helena Viñas Gaza
PhD
Hubrecht Institute
14:10 - 14:25
Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Brain Organoids Modelling of Genetic and Environmental Impact on Neurodevelopment
Nicolò Caporale
Postdoc
Human Technopole
14:25 - 14:50
Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Deciphering Gene Expression Regulation in Development Using Integrative Omics
Michiel Vermeulen (by remote)
Radbound Institute for Molecular Life Sciences, Radbound University, Nijmegen, The Netherlands
14:50 - 14:52
Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Functional Dissection of PRC2-Dependent Dysregulation in Weaver Syndrome through Cortical Brain Organoids
Martina Pezzali
PhD
Human Technopole
14:52 - 14:54
Session 5: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - The Decoupling of Brain and Face Development in Homo sapiens through Selection of Epigenetic Switches
Alessandro Vitriolo
Postdoc
IEO IRCCS
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Chair of Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Oliver Harschnitz
15:15 - 15:40
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Epitranscriptomic landscapes of pluripotent stem cell states
R. David Hawkins
Div. of Medical Genetics, Dpt. of Medicine, Dpt of Genome Sciences, Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, US
15:40 - 16:05
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
High Definition Modeling of Gene Dosage Imbalances Causing Neurodevelopmental Disorders
Giuseppe Testa
University of Milan, Human Technopole and European Institute of Oncology, Milan, Italy
16:05 - 16:20
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Recording Trunk-Like Structures Developmental Trajectories with Single-Cell Molecular Barcoding
Adriano Bolondi
PhD student
Max Planck Institute for Molecular Genetics
16:20 - 16:45
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
In Vitro Models of Germline Development and Disease
Harry Leitch
Medical Research Council, London Institute of Medical Sciences, London, UK
16:45 - 17:00
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Dynamics of CTCF and Cohesin Mediated Chromatin Looping Revealed by Live-Cell Imaging
Michele Gabriele
postd
Massachusetts Institute of Technology, Broad Institute of MIT and Harvard, Koch Institute of MIT.
17:00 - 17:02
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - A Functional Dissection of the Genetic Circuits Selected in Anatomically Modern Humans
Adrianos Skaros
PhD
IEO
17:02 - 17:04
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Benchmarking iPSCS-Derived Cerebellar Organoids Development
Davide Aprile
Postdoc
University of Milan
17:04 - 17:06
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - A Molecular Atlas of Hormonal Impact on Human Corticogenesis through Brain Organoids Modelling
Marco Tullio Rigoli
PHD
Istituto Europeo di Oncologia (IEO)
17:06 - 17:08
Session 6: Stem Cell Multi-omics Modelling in Health and Disease
Poster teaser - Benchmarking Brain Organoid Recapitulation of Fetal Corticogenesis
Cristina Cheroni
Computational Biologist
Human Technopole, Università degli Studi di Milano
6July
Coffee break
10:55 - 11:15
Session 7: Chromatin in Time
Chair of Session 7: Chromatin in Time
Davide Cittaro
Researcher
San Raffaele Hospital
09:00 - 09:25
Session 7: Chromatin in Time
Exploring the Role of Polycomb and MLL Complexes on Chromatin Topology, Stem Cell Differentiation, and Cancer
Luciano Di Croce
CRG - Center for Genomic Regulation, Barcelona, Spain
09:25 - 09:50
Session 7: Chromatin in Time
Smarcad1 Knockdown in ESC Impairs Retroviral Silencing by Depletion of Trim28 Binding and H3.3 Deposition
Sharon Schlesinger
The Hebrew University of Jerusalem, The Robert H Smith Faculty of Agriculture, Food and Environment, Jerusalem, Israel
09:50 - 10:05
Session 7: Chromatin in Time
SETα Protects from Aberrant H3K4me3 Removal in ESCs
Patrick Siang Lin Lim
PHD
Hebrew University of Jerusalem
10:05 - 10:30
Session 7: Chromatin in Time
Chromatin Profiling in Single Cells
Alexander van Oudenaarden
Hubrecht Institute, Utrecht, The Netherlands
10:30 - 10:55
Session 7: Chromatin in Time
Tracking Enhancer-promoter Communication in Real-time in Living Cells
Thomas Sexton
Institute of Genetics and Molecular and Cellular Biology, Strasbourg, France
Session 8: Chromatin in Time
Chair of Session 8: Chromatin in Time
Silvia Kirsten Nicolis
PI and Professor
Department of Biotechnology and Biosciences, University of Milano-Bicocca
11:15 - 11:40
Session 8: Chromatin in Time
Esrrb is a Cell Cycle Dependent Associated Factor Balancing Pluripotency and XEN Differentiation
Oren Ram
The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
11:40 - 11:42
Session 8: Chromatin in Time
Poster teaser - Combined Cell of Origin Stratification and Multi-Omics Lineage Tracing to Highlight Functional Determinants of High Grade Serous Ovarian Cancer Pathogenesis
Marta Sallese
PhD Student
European Institute of Oncology
11:42 - 11:44
Session 8: Chromatin in Time
Poster teaser - Heat Stress Effects on Transcriptome of Bovine Mesenchymal Stem Cells
Ivana Ribarski Chorev
PhD student
Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem
11:44 - 11:46
Session 8: Chromatin in Time
Poster teaser - The H33 Coding Genes Have Distinct Roles in Retroviral Silencing in Mouse Embryonic Stem Cells
Ayellet Tal
PhD Student
The Hebrew University in Jerusalem
11:46 - 12:11
Session 8: Chromatin in Time
The Yin and Yang of Overcoming Chromatin Barriers to Change Cell Fate
Kenneth Zaret
Perelman School of Medicine, University of Pennsylvania, Philadelphia, US
