Coffee Break
10:30 - 10:50
Coffee Break
14:54 - 15:15
Session 3: Chromatin Architecture across Replication, Transcription and SplicingChair of Session 3: Chromatin Architecture across Replication, Transcription and Splicing Chair person Francesco Ferrari Sala
Francesco Ferrari
Principal Investigator
IFOM
09:00 - 09:25
Session 3: Chromatin Architecture across Replication, Transcription and SplicingBeyond Motif: Guiding Sites of Transcription Factor Binding by DNA Modifications
Dirk Schubeler
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
09:25 - 09:40
Session 3: Chromatin Architecture across Replication, Transcription and SplicingEvolution Increases Stress-Response Complexity in Higher Primates Extending Rbfox1 Splicing Activity to LSD1 Modulation
Chiara Forastieri
POSTDOC
University of Milan
09:40 - 10:05
Session 3: Chromatin Architecture across Replication, Transcription and SplicingHistone Variants and Chaperones in Shaping Chromatin and Cell Fate
Genevieve Almouzni (by remote)
Centre de Recherche de l'Institut Curie, Paris, France
10:05 - 10:30
Session 3: Chromatin Architecture across Replication, Transcription and SplicingEnhancer Function in the 3D Genome: Is Close Enough Enough?
Wendy Bickmore
Medical Research Council Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK
10:50 - 10:52
Session 3: Chromatin Architecture across Replication, Transcription and SplicingPoster teaser - Hooked Up from a Distance Functional Study of 3D Enhancer-Promoter Interaction Networks in Neural Stem Cells, and their Relevance for Neurodevelopmental Disease
10:52 - 10:54
Session 3: Chromatin Architecture across Replication, Transcription and SplicingPoster teaser - A Network-Based Framework to Unravel Gene Regulation Dynamics during Craniofacial Development
Daniele Capocefalo
Postdoctoral Researcher
Human Technopole
10:54 - 10:56
Session 3: Chromatin Architecture across Replication, Transcription and SplicingPoster teaser - Understanding Early Embryogenesis Regulation Through Proteomics Approaches
Maria Teresa Alejo Vinogradova
PhD Candidate
Radboud University
Session 4: Stem Cell Multi-omics Modelling in Health and DiseaseChair of Session 4: Stem Cell Multi-omics Modelling in Health and Disease
10:56 - 11:21
Session 4: Stem Cell Multi-omics Modelling in Health and DiseaseSingle Cell Multi-omics Landscape of Development and Ageing
Wolf Reik (by remote)
Babraham Institute, Cambridge, UK
11:21 - 11:36
Session 4: Stem Cell Multi-omics Modelling in Health and DiseaseReplication Stress Induces Cell Fate Reprogramming in Embryonic Stem Cells
Vincenzo Costanzo
PI
IFOM • Istituto Fondazione di Oncologia Molecolare ETS
11:36 - 11:51
Session 4: Stem Cell Multi-omics Modelling in Health and DiseaseIntegrative Analysis of Aberrant Epigenetic Features in Triple Negative Breast Cancer
Tiziana Bonaldi
PI
European Institute of Oncology, Milan
11:51 - 12:16
Session 4: Stem Cell Multi-omics Modelling in Health and DiseaseiPSC-derived Brain Organoids Reveal Widespread DNA de-methylation in Huntington's Disease
Eran Meshorer
Edmond and Lily Center for Brain Sciences, The Hebrew University, Jerusalem, Israel
12:16 - 12:18
Session 4: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Multi-omics Profiling Uncovers Alterations in Thymic Epithelial Tumors and Mechanistic Insight into GTF2I Involvement
Sude Beskardes
Fellow
European Institute of Oncology
12:18 - 12:20
Session 4: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Prospective Isolation of Cancer Stem Cells by Single Cell Trained Sorting in High Grade Serous Ovarian Cancer
Bianca Barzaghi
PhD
Istituto Europeo di Oncologia
12:20 - 12:22
Session 4: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Deciphering Epigenetics Role in Huntington Disease Cell Lines
Paola Conforti
Tecnico di laboratorio
dipartimento di Bioscienze, Università degli Studi di Milano
12:22 - 12:24
Session 4: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Patient-Specific Modelling of Syndromic Autism Uncovering the Role of ADNP In Chromatin Dysregulation
Ludovico Rizzuti
Postdoc
European Institute of Oncology
12:24 - 12:26
Session 4: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Gabriele-De Vries Syndrome (GADEVS) Disentangling the Role of YY1 Across Human Neuronal Models at Single-Nuclei Resolution
Marlene F Pereira
PhD student
European Institute of Oncology (IEO)
12:26 - 12:28
Session 4: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - The Impact of Replication Stress on the Epigenome of Embryonic Stem Cells
Christelle El Kai
PhD
SEMM Foundation
Session 5: Stem Cell Multi-omics Modelling in Health and DiseaseChair of Session 5: Stem Cell Multi-omics Modelling in Health and Disease
13:30 - 13:55
Session 5: Stem Cell Multi-omics Modelling in Health and DiseaseGene Regulation and Cognition
Raymond Poot
Erasmus MC University Medical Center, Rotterdam, The Netherlands
13:55 - 14:10
Session 5: Stem Cell Multi-omics Modelling in Health and DiseaseSingle-Cell Study of Epigenetic Dynamics in Cell Diversification during Zebrafish Development
Helena Viñas Gaza
PhD
Hubrecht Institute
14:10 - 14:25
Session 5: Stem Cell Multi-omics Modelling in Health and DiseaseBrain Organoids Modelling of Genetic and Environmental Impact on Neurodevelopment
Nicolò Caporale
Postdoc
Human Technopole
14:25 - 14:50
Session 5: Stem Cell Multi-omics Modelling in Health and DiseaseDeciphering Gene Expression Regulation in Development Using Integrative Omics
Michiel Vermeulen (by remote)
Radbound Institute for Molecular Life Sciences, Radbound University, Nijmegen, The Netherlands
14:50 - 14:52
Session 5: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Functional Dissection of PRC2-Dependent Dysregulation in Weaver Syndrome through Cortical Brain Organoids
Martina Pezzali
PhD
Human Technopole
14:52 - 14:54
Session 5: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - The Decoupling of Brain and Face Development in Homo sapiens through Selection of Epigenetic Switches
Alessandro Vitriolo
Postdoc
IEO IRCCS
Session 6: Stem Cell Multi-omics Modelling in Health and DiseaseChair of Session 6: Stem Cell Multi-omics Modelling in Health and Disease
15:15 - 15:40
Session 6: Stem Cell Multi-omics Modelling in Health and DiseaseEpitranscriptomic landscapes of pluripotent stem cell states
R. David Hawkins
Div. of Medical Genetics, Dpt. of Medicine, Dpt of Genome Sciences, Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, US
15:40 - 16:05
Session 6: Stem Cell Multi-omics Modelling in Health and DiseaseHigh Definition Modeling of Gene Dosage Imbalances Causing Neurodevelopmental Disorders
Giuseppe Testa
University of Milan, Human Technopole and European Institute of Oncology, Milan, Italy
16:05 - 16:20
Session 6: Stem Cell Multi-omics Modelling in Health and DiseaseRecording Trunk-Like Structures Developmental Trajectories with Single-Cell Molecular Barcoding
Adriano Bolondi
PhD student
Max Planck Institute for Molecular Genetics
16:20 - 16:45
Session 6: Stem Cell Multi-omics Modelling in Health and DiseaseIn Vitro Models of Germline Development and Disease
Harry Leitch
Medical Research Council, London Institute of Medical Sciences, London, UK
16:45 - 17:00
Session 6: Stem Cell Multi-omics Modelling in Health and DiseaseDynamics of CTCF and Cohesin Mediated Chromatin Looping Revealed by Live-Cell Imaging
Michele Gabriele
postd
Massachusetts Institute of Technology, Broad Institute of MIT and Harvard, Koch Institute of MIT.
17:00 - 17:02
Session 6: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - A Functional Dissection of the Genetic Circuits Selected in Anatomically Modern Humans
17:02 - 17:04
Session 6: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Benchmarking iPSCS-Derived Cerebellar Organoids Development
Davide Aprile
Postdoc
University of Milan
17:04 - 17:06
Session 6: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - A Molecular Atlas of Hormonal Impact on Human Corticogenesis through Brain Organoids Modelling
Marco Tullio Rigoli
PHD
Istituto Europeo di Oncologia (IEO)
17:06 - 17:08
Session 6: Stem Cell Multi-omics Modelling in Health and DiseasePoster teaser - Benchmarking Brain Organoid Recapitulation of Fetal Corticogenesis
Cristina Cheroni
Computational Biologist
Human Technopole, Università degli Studi di Milano